Long term outcomes and prognostics of visceral leishmaniasis in HIV infected patients with use of pentamidine as secondary prophylaxis based on CD4 level: a prospective cohort study in Ethiopia.
Ermias DiroTansy EdwardsKoert RitmeijerHelina FikreCharles AbongomeraAderajew KibretClélia BardonneauPeninah SoipeiBrian MutindaRaymond OmolloJohan van GriensvenEduard E ZijlstraMonique WasunnaFabiana AlvesJorge AlvarAsrat HailuNeal AlexanderSéverine BlessonPublished in: PLoS neglected tropical diseases (2019)
The relapse-free survival rate for VL patients with HIV was low. Relapse-free survival of patients with CD4 count <200cells/μL given pentamidine secondary prophylaxis appeared to be comparable to patients with a CD4 count ≥200 cells/μL not given prophylaxis. Patients with relapsed VL are at higher risk for subsequent relapse and should be considered a priority for secondary prophylaxis, irrespective of their CD4 count.
Keyphrases
- free survival
- hiv infected
- induced apoptosis
- antiretroviral therapy
- cell cycle arrest
- nk cells
- acute lymphoblastic leukemia
- human immunodeficiency virus
- peripheral blood
- hiv positive
- cell death
- hepatitis c virus
- signaling pathway
- oxidative stress
- hiv aids
- diffuse large b cell lymphoma
- cell proliferation
- hodgkin lymphoma