Advanced Lipoprotein Analysis Shows Atherogenic Lipid Profile That Improves After Metreleptin in Patients with Lipodystrophy.

Alexandra B KinzerRobert D ShamburekMarissa LightbourneRanganath MuniyappaRebecca J Brown

Published in: Journal of the Endocrine Society (2019)

Patients with lipodystrophy had an atherogenic lipoprotein profile at baseline consistent with elevated CVD risk, which improved after metreleptin treatment. The presence of fasting chylomicrons in a subset of patients with lipodystrophy suggests saturation of chylomicron clearance by lipoprotein lipase.

Keyphrases

low density lipoprotein
blood glucose
insulin resistance
adipose tissue
blood pressure
weight loss