Disability trajectories by progression independent of relapse activity status differ in pediatric, adult and late-onset multiple sclerosis.

Marta SimoneGiuseppe LucisanoTommaso GuerraDamiano PaolicelliMaria A RoccaVincenzo Brescia MorraFrancesco PattiPietro AnnovazziClaudio GasperiniGiovanna De LucaDiana FerraroLucia MargariFranco GranellaCarlo PozzilliSilvia RomanoPaola PeriniRoberto BergamaschiMaria Gabriella ConiglioGiacomo LusMarika VianelloAlessandra LugaresiEmilio PortaccioMassimo FilippiMaria Pia AmatoPietro Iaffaldanonull null

Published in: Journal of neurology (2024)

Age is relevant in determining disability progression in MS. POMS shows a less steep increase in EDSS scores over time than older patients. The effect of PIRA in accelerating EDSS progression is less pronounced in POMS than in AOMS and LOMS.

Keyphrases

multiple sclerosis
late onset
early onset
white matter
mass spectrometry
depressive symptoms
ms ms
young adults