Antimicrobial dressing of silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites.
Graziele Louize Policarpio da SilvaLaís Caroline de Assunção MoraisJuliana Bonametti OlivatoJuliano MariniPriscileila Colerato FerrariPublished in: Journal of biomaterials applications (2021)
(Bio)nanocomposites have been studied for biomedical applications, including the treatment of wounds. However, wound infection is one of the main problems of wound care management, and the use of wound dressings with antibacterial agents is essential. This work focused on developing and characterizing silver sulfadiazine-loaded halloysite/cassava starch-based (bio)nanocomposites potentially suitable as antimicrobial dressing. Silver sulfadiazine was complexed inside the halloysite nanotubes lumen, and the drug-loaded nanotubes were incorporated in thermoplastic starch dispersion, forming the (bio)nanocomposites. The silver sulfadiazine-loaded halloysite and the (bio)nanocomposite were characterized by zeta potential, scanning electron microscopy, X-ray diffraction, and infrared spectroscopy. The dressing properties of (bio)nanocomposites (water vapor permeability and mechanical stability) and their antimicrobial efficacy by Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were also evaluated. Physicochemical studies suggested the silver sulfadiazine-loaded halloysite complexation (zeta potential of -38.9 mV) and its interactions with the starch forming the nanocomposites. The silver sulfadiazine-loaded halloysite/starch-based (bio)nanocomposites possessed a homogeneous and organized structure. Also, they had mechanical properties to be used as a dressing (13.73 ± 3.09 MPa and 3.17 ± 1.28% of elongation at break), and its permeability (6.18 ± 0.43 (10-13) g.Pa-1.s-1.m-1) could be able to maintain the environmental moisture at the wound surface. Besides that, the (bio)nanocomposites acted against the studied bacteria, being a potential contact antimicrobial and biodegradable wound dressing. Finally, the developed (bio)nanocomposites are semi-occlusive and good candidates for dry wounds to be widely in vitro and in vivo tested as controlled silver sulfadiazine delivery dressing.
Keyphrases
- wound healing
- reduced graphene oxide
- gold nanoparticles
- staphylococcus aureus
- drug delivery
- carbon nanotubes
- silver nanoparticles
- electron microscopy
- visible light
- pseudomonas aeruginosa
- escherichia coli
- cancer therapy
- biofilm formation
- healthcare
- high resolution
- emergency department
- palliative care
- cystic fibrosis
- magnetic resonance
- magnetic resonance imaging
- quality improvement
- mental health
- multidrug resistant
- pain management
- ultrasound guided
- acinetobacter baumannii
- solid state
- mass spectrometry