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Development of AITC-induced dermal blood flow as a translational in vivo biomarker of TRPA1 activity in human and rodent skin.

Victory JosephXiaoying YangSimon S GaoJustin ElstrottRobby M WeimerWiebke TheessCory ThrasherNand SinghJoseph LinRebecca N Bauer
Published in: British journal of clinical pharmacology (2020)
AITC-induced DBF is a suitable target engagement biomarker of TRPA1 activity for preclinical and clinical studies of TRPA1 antagonists.
Keyphrases
  • blood flow
  • high glucose
  • endothelial cells
  • diabetic rats
  • drug induced
  • social media
  • oxidative stress
  • wound healing
  • stem cells
  • soft tissue
  • cell therapy
  • stress induced