Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs.

Shreoshi Pal Choudhuri Luc Girard Jun Yi Stanley Lim Jillian F Wise Braeden Freitas Di Yang Edmond Wong Seth Hamilton Victor D Chien Yoon Jung Kim Collin Gilbreath Jun Zhong Sarah Phat David T Myers Camilla L Christensen Hanieh Mazloom-Farsibaf Marcello Stanzione Kwok-Kin Wong Yin Pun Hung Anna F Farago Catherine B Meador Nicholas J Dyson Michael S Lawrence Sihan Wu Benjamin J Drapkin

Published in: Cancer discovery (2024)

SCLC is initially chemosensitive, but acquired cross-resistance renders this disease refractory to further treatment and ultimately fatal. The genomic drivers of this transformation are unknown. We use a population of PDX models to discover that amplifications of MYC paralogs on ecDNA are recurrent drivers of acquired cross-resistance in SCLC. This article is featured in Selected Articles from This Issue, p. 695.

Keyphrases

small cell lung cancer
transcription factor
nucleic acid
gene expression
cell free
single molecule
dna methylation
brain metastases
genome wide
label free