CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma.

Anju Wadhwa Sinan Wang Bonell Patiño Escobar Anil Parsram Bidkar Kondapa Naidu Bobba Emily Chan Niranjan Meher Scott Bidlingmaier Yang Su Suchi Dhrona Huimin Geng Vishesh Sarin Henry F VanBrocklin David M Wilson Jiang He Li Zhang Veronica Steri Sandy W Wong Thomas G Martin Youngho Seo Bin Liu Arun P Wiita Robert Richard Flavell

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Our study showed that the CD46-targeted probe [89Zr]Zr-DFO-YS5 can successfully image CD46-expressing multiple myeloma xenografts in murine models, and [225Ac]Ac-DOTA-YS5 can effectively inhibit the growth of multiple myeloma. These results demonstrate that CD46 is a promising theranostic target for multiple myeloma, with the potential for clinical translation.

Keyphrases

multiple myeloma
pet imaging
pet ct
stem cells
computed tomography
deep learning
positron emission tomography
mesenchymal stem cells
quantum dots
machine learning
fluorescence imaging
human health
single molecule
chemotherapy induced