Effect of Germline Mutations in Homologous Recombination Repair Genes on Overall Survival of Patients with Pancreatic Adenocarcinoma.
Siddhartha YadavPashtoon Murtaza KasiWilliam R BamletThanh P HoEric C PolleyChunling HuSteven N HartKari G RabeNicholas J BoddickerRohan D GnanaolivuKun Y LeeTricia H LindstromGloria M PetersenFergus J CouchRobert R McWilliamsPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
This study demonstrates that germline mutation carrier status in PDAC is associated with longer OS compared with noncarriers. Further research into tumor biology and response to platinum-based chemotherapy in germline mutation carriers with PDAC are needed to better understand the association with longer OS.