ULK1 Depletion Protects Mice from Diethylnitrosamine-Induced Hepatocarcinogenesis by Promoting Apoptosis and Inhibiting Autophagy.

Ting DuanXin YangJingyu KuangWenjie SunJin LiJuan GeMohan ZhangXiaobo CaiPeilin YuJun YangXinqiang Zhu

Published in: Journal of hepatocellular carcinoma (2023)

ULK1 deficiency prevented hepatocarcinogenesis and inhibited hepatic tumor growth, and might be a molecular target for the prevention and treatment of HCC.

Keyphrases

endoplasmic reticulum stress
oxidative stress
cell death
signaling pathway
diabetic rats
high glucose
cell cycle arrest
replacement therapy
drug induced
high fat diet induced
type diabetes
combination therapy
metabolic syndrome
single molecule
skeletal muscle
endothelial cells