Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor.

Le Hien GiangKuo-Sheng WuWei-Chung LeeShing-Shung ChuAnh Duy DoChun A ChangouHuy Minh TranTsung-Han HsiehHsin-Hung ChenChia-Ling HsiehShian-Ying SungAlice L YuYun YenTai-Tong WongChe-Chang Chang

Published in: Journal of experimental & clinical cancer research : CR (2023)

Collectively, our study uncovers the oncogenic functions of RRM2 in ATRT cell lines, and highlights the therapeutic potential of targeting RRM2 in ATRT. The promising effect of COH29 on ATRT suggests its potential suitability for clinical trials as a novel therapeutic approach for ATRT.

Keyphrases

dna damage response
clinical trial
cancer therapy
oxidative stress
dna repair
endoplasmic reticulum stress
signaling pathway
cell death
cell cycle arrest
cell proliferation
phase ii
study protocol
pi k akt