Optimizing the effective doses of mitomycin C, 5-fluorouracil, and their combination on cultivated basal cell carcinoma.

Sahar BalagholiMaryam AletahaMozhgan Rezaei KanaviSamira KaramiRasul DabbaghiParisa Ashtar Nakhaie

Published in: Arquivos brasileiros de oftalmologia (2021)

Our in vitro results revealed that the effective doses of mitomycin C and 5-fluorouracil on cultivated basal cell carcinoma were optimized. Mitomycin C was more effective in inducing the apoptosis of basal cell carcinoma than 5-fluorouracil and their combination. The intralesional injections of the optimum dose of mitomycin C could be proposed for the nonsurgical treatment of advanced eyelid basal cell carcinoma.

Keyphrases

basal cell carcinoma
oxidative stress
cell death
endoplasmic reticulum stress
single cell
cell cycle arrest
ultrasound guided
cell proliferation
signaling pathway