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The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response.

Andrea DevecchiLoris De CeccoMatteo DugoDonata PensoGianpaolo DagradaSilvia BrichSilvia StacchiottiMarialuisa SensiSilvana CanevariSilvana Pilotti
Published in: Cancer communications (London, England) (2018)
The emerging picture is an extreme inter-tumor heterogeneity, characterized by the concurrent deregulation of the DDR and MErT/EMT dynamic and plastic programs that could favour genomic instability and explain the refractory DSRCT profile.
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