The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response.
Andrea DevecchiLoris De CeccoMatteo DugoDonata PensoGianpaolo DagradaSilvia BrichSilvia StacchiottiMarialuisa SensiSilvana CanevariSilvana PilottiPublished in: Cancer communications (London, England) (2018)
The emerging picture is an extreme inter-tumor heterogeneity, characterized by the concurrent deregulation of the DDR and MErT/EMT dynamic and plastic programs that could favour genomic instability and explain the refractory DSRCT profile.
Keyphrases
- epithelial mesenchymal transition
- dna damage response
- single cell
- immune response
- transforming growth factor
- public health
- signaling pathway
- genome wide
- climate change
- squamous cell carcinoma
- copy number
- toll like receptor
- dendritic cells
- bone marrow
- gene expression
- dna damage
- locally advanced
- oxidative stress
- radiation therapy
- bioinformatics analysis
- rectal cancer