G-CSFR antagonism reduces mucosal injury and airways fibrosis in a virus-dependent model of severe asthma.

Hao WangChristian AloeJonathan McQualterAngelica PapanicolaouRoss VlahosNick WilsonSteven Bozinovski

Published in: British journal of pharmacology (2021)

We have shown that antagonising G-CSFR-dependent neutrophilic inflammation reduced pathological disruption of the mucosal barrier and airways fibrosis in an IAV-induced severe asthma model.

Keyphrases

cystic fibrosis
oxidative stress
ulcerative colitis
high glucose
endothelial cells
stress induced