The sphingosine analog fingolimod (FTY720) enhances tone and contractility of rat gastric fundus smooth muscle.

M KraftU K ZettlT NoackRobert Patejdl

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)

FTY720 increases tone and contractile responses to depolarization in gastric fundus smooth muscle by triggering calcium entry and calcium sensitization in a S1P receptor-dependent manner. Taken together, the experimental results presented in this work suggest that FTY720 may increase gastric tone and contractility in patients.

Keyphrases

smooth muscle
end stage renal disease
ejection fraction
multiple sclerosis
diabetic retinopathy
oxidative stress
prognostic factors
peritoneal dialysis