MicroRNA-217: a therapeutic and diagnostic tumor marker.

Amir Abbas HamidiMalihe ZangoueDaniel KashaniAmir Sadra ZangoueiHamid Reza RahimiMohammad Reza AbbaszadeganMeysam Moghbeli

Published in: Expert review of molecular diagnostics (2021)

It was observed that miR-217 mainly exerts its function by regulation of the transcription factors during tumor progressions. The WNT, MAPK, and PI3K/AKT signaling pathways were also important molecular targets of miR-217 in different cancers. The present review clarifies the molecular biology of miR-217 and paves the way of introducing miR-217 as a non-invasive diagnostic marker and therapeutic target in cancer therapy.

Keyphrases

cell proliferation
pi k akt
signaling pathway
long non coding rna
long noncoding rna
cancer therapy
cell cycle arrest
transcription factor
stem cells
epithelial mesenchymal transition
drug delivery
oxidative stress
cell death
single molecule