The role of vascular endothelial growth factor, interleukin 8, and insulinlike growth factor in sustaining autophagic DIRAS3-induced dormant ovarian cancer xenografts.

Weiqun MaoHaley L PetersMargie N SuttonAaron F OrozcoLan PangHailing YangZhen LuRobert C Bast

Published in: Cancer (2019)

Treatment with a combination of anti-VEGF, anti-IL-8, and anti-IGF receptor antibodies prevented the outgrowth of dormant cells and prolonged survival in a preclinical model.

Keyphrases

vascular endothelial growth factor
growth factor
endothelial cells
induced apoptosis
high glucose
stem cells
binding protein
signaling pathway
endoplasmic reticulum stress
combination therapy
free survival
replacement therapy