The protective influence of TREM2 on the VPA-induced ASD model is attributed to its inhibition of the P38 MAPK pathway, this protective effect may be achieved by promoting the polarization of microglia to anti-inflammatory phenotype and improving the neuronal synaptic development.
Keyphrases
- autism spectrum disorder
- signaling pathway
- anti inflammatory
- inflammatory response
- neuropathic pain
- attention deficit hyperactivity disorder
- epithelial mesenchymal transition
- pi k akt
- prefrontal cortex
- diabetic rats
- oxidative stress
- cell proliferation
- blood brain barrier
- working memory
- endoplasmic reticulum stress