Diffusion decrease in normal-appearing white matter structures following photon or proton irradiation indicates differences in regional radiosensitivity.

Katharina WitzmannFelix RaschkeTim WesemannSteffen LöckFabian FunerJennifer LinnEsther G C Troost

Published in: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2024)

Significant changes in DTI for WM substructures were found even at low radiation doses. These findings may prompt new radiation dose constraints sparing the vulnerable structures from damage and subsequent side-effects.

Keyphrases

white matter
high resolution
multiple sclerosis
oxidative stress
radiation induced
robot assisted
living cells
radiation therapy
minimally invasive
single molecule
monte carlo