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Identification of 2-Methylthio-methylenethio-N 6 -(cis-4-hydroxyisopentenyl)adenosine (msms 2 io 6 A 37 ) as a Novel Modification at Adenosine 37 of tRNAs from Salmonella typhimurium.

Marouane LibiadThierry DoukiMarc FontecaveMohamed Atta
Published in: Chembiochem : a European journal of chemical biology (2023)
Post-transcriptional modifications of tRNA nucleotide are important determinants in folding, structure and function. We have successfully identified and characterized a new modified base named 2-methylthio-methylenethio-N 6 -(cis-4-hydroxyisopentenyl)adenosine, which is present at position 37 in some tRNAs. We also showed that this new modified adenosine is derived from the known 2-methylthio-methylenethio-N 6 -(isopentenyl)adenosine nucleoside by a catalytic cycle of the tRNA-diiron monooxygenase, MiaE, present in Salmonella typhimurium.
Keyphrases
  • listeria monocytogenes
  • protein kinase
  • escherichia coli
  • gene expression
  • transcription factor
  • molecular dynamics simulations