TRAV26-2 T CELL RECEPTOR EXPRESSION IS ASSOCIATED WITH MUCOSAL LYMPHOCYTE RESPONSE TO WHEAT PROTEINS IN FUNCTIONAL DYSPEPSIA PATIENTS.
Grace L BurnsMichael PotterAndrea MatheJessica BruceKyra MinahanJessica L BarnesJennifer PryorCheenie NievaSimonne SherwinAnnalisa CuskellyThomas FairlieRaquel CameronSteven BollipoMudar Zand IraniRobert FosterLay T GanAyesha ShahNatasha KoloskiPaul S FosterJay C HorvatMarjorie M WalkerNick PowellMartin VeyseyKerith DuncansonGerald HoltmannNicholas J TalleySimon KeelyPublished in: Clinical and translational gastroenterology (2023)
Our findings suggest that gliadin exposure provokes a duodenal effector Th2-like response in FD patients, supporting the notion that food antigens drive responses in some patients. Further, these findings suggest that altered lymphocyte responses to wheat proteins play a role in FD pathogenesis.