miR-449a inhibits cell proliferation, migration, and inflammation by regulating high-mobility group box protein 1 and forms a mutual inhibition loop with Yin Yang 1 in rheumatoid arthritis fibroblast-like synoviocytes.
Yongsong CaiCongshan JiangJialin ZhuKe XuXiaoyu RenLin XuPeijing HuBo WangQiling YuanYuanxu GuoJian SunPeng XuYusheng QiuPublished in: Arthritis research & therapy (2019)
Our results reveal the regulatory mechanism of HMGB1 in RA and demonstrate that miR-449a is a crucial molecule in RA pathogenesis and a suitable candidate for miRNA replacement therapies in RA.
Keyphrases
- rheumatoid arthritis
- cell proliferation
- disease activity
- transcription factor
- long non coding rna
- ankylosing spondylitis
- cell cycle
- interstitial lung disease
- long noncoding rna
- binding protein
- oxidative stress
- systemic lupus erythematosus
- pi k akt
- genome wide
- gene expression
- amino acid
- small molecule
- signaling pathway