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Preliminary evidence of a relationship between sleep spindles and treatment response in epileptic encephalopathy.

John R McLarenYancheng LuoHunki KwonWen ShiMark A KramerCatherine J Chu
Published in: bioRxiv : the preprint server for biology (2023)
These findings confirm thalamocortical disruption in EE-SWAS, identify a mechanism through which benzodiazepines may support cognitive recovery, and introduce sleep spindles as a promising mechanistic biomarker to detect treatment response in severe epileptic encephalopathies.
Keyphrases
  • sleep quality
  • early onset
  • physical activity
  • drug induced