Mast cell-derived serotonin enhances methacholine-induced airway hyperresponsiveness in house dust mite-induced experimental asthma.

Erika Mendez-EnriquezPerla Abigail Alvarado-VazquezWillem AbmaOscar E SimonsonSergey RodinThorsten B FeyerabendHans-Reimer RodewaldAndrei MalinovschiChrister JansonMikael AdnerJenny Hallgren

Published in: Allergy (2021)

Methacholine activates mast cells to release 5-HT, which by acting on 5-HT2A receptors enhances bronchoconstriction and AHR. Thus, M3-directed asthma treatments like tiotropium may also act by targeting mast cells.

Keyphrases

high glucose
chronic obstructive pulmonary disease
allergic rhinitis
diabetic rats
drug induced
endothelial cells
health risk
human health
polycyclic aromatic hydrocarbons