BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1.

Yufeng ZhangMin YangSheng ZhangZhiqiang YangYufan ZhuYi WangZhe ChenXuan LvZan HuangYuanlong XieLin Cai

Published in: Cell & bioscience (2022)

Our research reveals a novel Bhlhe40/c-Fos/Nfatc1 axis involved in regulating osteoclastogenesis and shows that osteoporosis caused by estrogen deficiency and aging can be rescued by regulating Bhlhe40 in mice. This may help in the development of a new strategy for the treatment of osteoporosis.

Keyphrases

bone mineral density
bone loss
postmenopausal women
lps induced
body composition
replacement therapy
high fat diet induced
estrogen receptor
metabolic syndrome
inflammatory response
soft tissue
skeletal muscle
bone regeneration
wild type