Penetrance of Parkinson's Disease in LRRK2 p.G2019S Carriers Is Modified by a Polygenic Risk Score.

Hirotaka IwakiCornelis BlauwendraatMary B MakariousSara Bandrés-CigaHampton L LeonardJ Raphael GibbsDena G HernandezSonja W ScholzFaraz Faghrinull nullMike A NallsAndrew B Singleton

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

Our results suggest that there is a genetic contribution for penetrance of PD among p.G2019S carriers. These results have important etiological consequences and potential impact on the selection of subjects for clinical trials. © 2020 International Parkinson and Movement Disorder Society.

Keyphrases

clinical trial
genome wide
copy number
human health
open label
risk assessment
phase iii