Neoadjuvant chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: Meta-analysis and trial sequential analysis of randomized controlled trials.

Shahab Hajibandeh Shahab Hajibandeh Christina Intrator Karim Hassan Mantej Sehmbhi Jigar Shah Eshan Mazumdar Ambareen Kausar Thomas Satyadas

Published in: Annals of hepato-biliary-pancreatic surgery (2022)

Neoadjuvant CRT might be beneficial for patients with BRPC, but not for patients with RPC. Nevertheless, the best available evidence does not include contemporary chemotherapy regimens. Patients with RPC and those with BRPC should not be combined in the same cohort in future studies.

Keyphrases

locally advanced
rectal cancer
squamous cell carcinoma
systematic review
radiation therapy
case control
minimally invasive
coronary artery bypass
meta analyses
clinical trial
study protocol
phase iii
phase ii
cardiac resynchronization therapy
coronary artery disease
atrial fibrillation
open label