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Repeated exposure to JWH-018 induces adaptive changes in the mesolimbic and mesocortical dopaminergic pathways, glial cells alterations, and behavioural correlates.

Nicholas PintoriMaria Paola CastelliCristina MilianoNicola SimolaPaola FaddaLiana FattoreMaria SchermaMaria Grazia EnnasRafaela MostallinoGiovanna FloreMarta De FeliceClaudia SaghedduMarco PistisGaetano Di ChiaraMaria Antonietta De Luca
Published in: British journal of pharmacology (2021)
Repeated exposure to JWH-018 may provide a useful model to clarify the detrimental effects of recurring use of Spice/K2 drugs.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • endoplasmic reticulum stress
  • oxidative stress
  • signaling pathway
  • cell death
  • cell proliferation
  • spinal cord
  • pi k akt