Copper-Catalyzed C7-Selective C-H/N-H Cross-Dehydrogenative Coupling of Indolines with Sulfoximines.

Cu-catalyzed cross-dehydrogenative coupling of the C7 C-H bond of indolines with sulfoximines has been accomplished. The reaction can be extended to the cross-dehydrogenative coupling of N -aryl 7-azaindoles with monoselectivity. The use of first-row copper catalysis, substrate scope, and late-stage synthetic applications are the important practical features.