Proteomic Risk Score of Increased Respiratory Susceptibility: A Multi-Cohort Study.
Gabrielle Y LiuAndrew S PerryGeorge R WashkoEric Farber-EgerLaura A ColangeloQuanhu ShengQuinn WellsXiaoning HuangBharat ThyagarajanWeihua GuanShaina J AlexandriaRaúl San José EstéparRussell P BowlerAnthony Joseph EspositoSadiya S KhanRavi V ShahBina ChoiRavi KalhanPublished in: American journal of respiratory and critical care medicine (2024)
A proteomic signature of increased respiratory susceptibility identifies people at risk of respiratory death, incident COPD, and respiratory exacerbations. This susceptibility score is comprised of proteins with well-known and novel associations with lung health and holds promise for the early detection of lung disease without requiring years of spirometry measurements.