Efficacy and Safety of Diclofenac-Hyaluronate Conjugate (Diclofenac Etalhyaluronate) for Knee Osteoarthritis: A Randomized Phase III Trial in Japan.

Yoshihiro NishidaKazuyuki KanoYuji NobuokaTakayuki Seo

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Our findings indicate that treatment with DF-HA results in significant improvement in the WOMAC pain subscale score compared to placebo over 12 weeks. Anaphylactic reactions were observed, and further safety evaluation is needed.

Keyphrases

phase iii
knee osteoarthritis
open label
clinical trial
phase ii
double blind
placebo controlled
chronic pain
pain management
neuropathic pain
study protocol
spinal cord injury
cancer therapy
drug delivery
combination therapy
gestational age
preterm birth
smoking cessation