Antiplasmodial profile of selected compounds from Malaria Box: in vitro evaluation, speed of action and drug combination studies.

Guilherme Eduardo de Souza Renata Vieira Bueno Juliana Oliveira de Souza Camila Lima Zanini Fábio Cardoso Cruz Glaucius Oliva Rafael Victorio Carvalho Guido Anna Caroline Campos Aguiar

Published in: Malaria journal (2019)

The findings in this paper shed light on the relationship among the speed of action, molecular target and combinatory profile and identified new hits with in vivo activity as candidates for anti-malarial combination therapy.

Keyphrases

combination therapy
plasmodium falciparum
transcription factor
binding protein
emergency department
case control
single molecule