Chronic lymphocytic leukemia (CLL) is a B-cell malignancy characterized by profound alterations and defects in the T-cell compartment. This observation has gained renewed interest as T-cell treatment strategies, which are successfully applied in more aggressive B-cell malignancies, have yielded disappointing results in CLL. Despite ongoing efforts to understand and address the observed T-cell defects, the exact mechanisms and nature underlying this dysfunction remain largely unknown. In this review, we examine the supporting signals from T cells to CLL cells in the lymph node niche, summarize key findings on T-cell functional defects, delve into potential underlying causes, and explore novel strategies for reversing these deficiencies. Our goal is to identify strategies aimed at resolving CLL-induced T-cell dysfunction which, in the future, will enhance the efficacy of autologous T-cell-based therapies for CLL patients.
Keyphrases
- chronic lymphocytic leukemia
- lymph node
- oxidative stress
- end stage renal disease
- induced apoptosis
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- bone marrow
- prognostic factors
- squamous cell carcinoma
- cell cycle arrest
- quality improvement
- current status
- intellectual disability
- radiation therapy
- mesenchymal stem cells
- autism spectrum disorder
- platelet rich plasma
- density functional theory
- locally advanced