Nefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation.

Seon-Hee OhMyung Ha YoonKyung Joon LimByung Sik YuIn Gook JeeKi Tae Jung

Published in: BMC anesthesiology (2018)

Collectively, the mode of action of nefopam on neuropathic pain appears to be associated with downregulation of phospho-JNK and autophagy, as well as modulation of the immune response.

Keyphrases

neuropathic pain
spinal cord
signaling pathway
cell death
immune response
spinal cord injury
endoplasmic reticulum stress
induced apoptosis
oxidative stress
tyrosine kinase
toll like receptor