Novel insights into the SLC7A11-mediated ferroptosis signaling pathways in preeclampsia patients: identifying pannexin 1 and toll-like receptor 4 as innovative prospective diagnostic biomarkers.

Sarah Ragab Abd El-KhalikRowida Raafat IbrahimMuhammad Tarek Abdel GhafarDoaa ShatatOmnia Safwat El-Deeb

Published in: Journal of assisted reproduction and genetics (2022)

Therefore, Panx1 and TLR4 are suggested to induce ferroptosis in PE via SLC7A11-mediated signaling pathways, offering a novel perspective on PE pathogenesis and novel diagnostic tools for PE.

Keyphrases

toll like receptor
signaling pathway
inflammatory response
nuclear factor
cell death
immune response
end stage renal disease
ejection fraction
newly diagnosed
pi k akt
early onset
prognostic factors
induced apoptosis
patient reported outcomes
pregnancy outcomes