Integrative Analyses of Biomarkers Associated with Endoplasmic Reticulum Stress in Ischemic Stroke.

Xiaoting Zhang Xi Li Jinyan Gu Jingpei Guo Jiayao Chen Ke Zhang Junfeng Liu Jiani Liu Chao Peng Hanwei Liu Bin Zhou

Published in: Computational and mathematical methods in medicine (2022)

By integrating and analyzing the two gene expression data profiles, it can be inferred that ERS may be involved in the development of neuronal apoptosis following IS via immune homeostasis. The identified hub genes, which are associated with immune cell infiltration, may serve as potential biomarkers for relative diagnosis and therapy.

Keyphrases

endoplasmic reticulum stress
gene expression
induced apoptosis
bioinformatics analysis
network analysis
dna methylation
genome wide
electronic health record
atrial fibrillation
big data
machine learning
oxidative stress
data analysis
mesenchymal stem cells
cell proliferation
signaling pathway
brain injury