(Pro)renin receptor mediates tubular epithelial cell pyroptosis in diabetic kidney disease via DPP4-JNK pathway.

Shiying XieShicong SongSirui LiuQiong LiWei ZouJianting KeCheng Wang

Published in: Journal of translational medicine (2024)

This study identified the significant role of PRR in the pathogenesis of DKD; specifically, PRR promoted tubular epithelial cell pyroptosis via DPP4 mediated signaling, highlighting that PRR could be a promising therapeutic target in DKD.

Keyphrases

nlrp inflammasome
type diabetes
signaling pathway
high glucose
cell death
anti inflammatory
wound healing
angiotensin converting enzyme
angiotensin ii