Moderate dose alcohol protects against serum amyloid protein A1-induced endothelial dysfunction via both notch-dependent and notch-independent pathways.

Naresh K RajendranWeimin LiuCharles Y Chiu Paul A Cahill Eileen M Redmond

Published in: Alcoholism, clinical and experimental research (2021)

EtOH at moderate levels protects against SAA1-induced endothelial activation via both Notch-dependent and Notch-independent mechanisms. EtOH's maintenance of endothelium in a nonactivated state would be expected to preserve vessel homeostasis and protect against atherosclerosis development.

Keyphrases

cell proliferation
high glucose
diabetic rats
endothelial cells
high intensity
drug induced
type diabetes
small molecule