A marine fungus-derived nitrobenzoyl sesquiterpenoid suppresses receptor activator of NF-κB ligand-induced osteoclastogenesis and inflammatory bone destruction.

Yanhui TanWende DengYueyang ZhangMinhong KeBinhua ZouXiaowei LuoJianbin SuYiyuan WangJialan XuKutty Selva NandakumarYonghong LiuXue-Feng Zhou Xiaojuan Li

Published in: British journal of pharmacology (2020)

These results highlighted nitrobenzoyl sesquiterpenoid 4 as a novel inhibitor of osteoclast differentiation. This marine-derived sesquiterpenoid is a promising lead compound for the treatment of osteolytic diseases.

Keyphrases

bone loss
signaling pathway
nuclear factor
lps induced
oxidative stress
diabetic rats
high glucose
bone mineral density
drug induced
immune response
combination therapy
soft tissue
body composition
postmenopausal women
binding protein