Therapeutic Effect of Donepezil on Neuroinflammation and Cognitive Impairment after Moderate Traumatic Brain Injury.
Dong Hyuk YounYounghyurk LeeSung Woo HanJong-Tae KimHarry JungGui Seung HanJung In YoonJae Jun LeeJin-Pyeong JeonPublished in: Life (Basel, Switzerland) (2024)
Donepezil treatment may be beneficial in improving cognitive impairment in the early phase of moderate traumatic brain injury by ameliorating neuroinflammation, as well as autophagy and mitophagy.
Keyphrases
- cognitive impairment
- traumatic brain injury
- high intensity
- spinal cord injury
- cell death
- endoplasmic reticulum stress
- signaling pathway
- oxidative stress
- white matter
- cerebral ischemia
- multiple sclerosis
- lps induced
- severe traumatic brain injury
- brain injury
- replacement therapy
- subarachnoid hemorrhage
- smoking cessation
- functional connectivity