β-patchoulene alleviates cognitive dysfunction in a mouse model of sepsis associated encephalopathy by inhibition of microglia activation through Sirt1/Nrf2 signaling pathway.
Ye TianLin WangXiaojing FanHui ZhangZhiwei DongTianzhu TaoPublished in: PloS one (2023)
In this study, we found that β-PAE significantly altered sepsis induced neuroinflammation and microglia activation, thus reversed the cognitive decline and improved the peripheral immune function. The neuroprotective effects were possibly mediated by the activation of Sirt1/Nrf2/HO-1 pathway. β-PAE might serve as a promising therapeutic agent for SAE prevention and treatment.
Keyphrases
- cognitive decline
- oxidative stress
- mouse model
- signaling pathway
- mild cognitive impairment
- acute kidney injury
- intensive care unit
- inflammatory response
- diabetic rats
- pi k akt
- neuropathic pain
- septic shock
- ischemia reperfusion injury
- lipopolysaccharide induced
- spinal cord injury
- spinal cord
- cognitive impairment
- blood brain barrier
- drug induced
- combination therapy
- cerebral ischemia
- endothelial cells
- endoplasmic reticulum stress