QTc prolongation during ciprofloxacin and fluconazole combination therapy: prevalence and associated risk factors.
Florine A BergerNico MonadianNatasja M S De GrootBart SantbergenHeleen van der SijsMatthijs L BeckerAnnoek E C BroersTeun van GelderPatricia Maria Lucia Adriana van den BemtPublished in: British journal of clinical pharmacology (2017)
The prevalence of QTc prolongation in patients using ciprofloxacin and fluconazole is low compared with the prevalence in the general population, which varies from 5% to 11%. In addition, no risk factors were found. Given the low prevalence, routine ECG monitoring in patients on this therapy should be reconsidered.