Renal function in children infected with Schistosoma haematobium: a case-control study of an endemic Ghanaian community.

Schistosomiasis has been associated with kidney diseases leading to serious health problems especially in advanced cases. Most studies have used renal biopsy, and ultrasonography in the diagnosis of renal damage among urogenital schistosomiasis affected individuals. This study assessed serum urea, creatinine, and eGFR as biochemical markers of renal abnormalities in children with urogenital schistosomiasis (Schistosoma haematobium) at a resource limited setting in Sorodofo-Abaasa in the Central Region of Ghana. A case-control study was conducted among 116 basic school children aged 9 to 17 years from January 2015 to May 2015 at Sorodofo-Abaasa in the Abura Asebu Kwamankese District of the Central Region of Ghana. A pre-tested questionnaire was used to obtain information on age, sex, guardian's occupation, water contact activities, history of gross haematuria and history of medication. Participants weight and height were measured using a bathroom scale (Zhongshan Camry Electronic Co. Ltd, Guangdong-China) and a wall-mounted ruler to the nearest 0.1 kg and 0.1 cm respectively. Approximately 4 ml of venous blood sample was collected from the median cubital vein of the study participants and used for the estimation of serum urea and creatinine levels. eGFR (mL/min/1.73 m2) was calculated using the Schwartz equation. The average ages of the cases and the controls recruited in this study were 12.7 ± 1.0 and 12. ± 2.6 years respectively. The median (minimum-maximum) did not differ between cases and controls with regards to eGFR [115.92(62.40-164.98) vs 112.50(51.82-170.36; p = 0.806], serum creatinine [57.20(28.91-84.67) vs 58.19(25.17-90.21); p = 0.876], and urea [9.82(5.80-13.74) vs 10.21(7.29-13.03); p = 0.586]. Hyperfiltration though statistically similar (p = 0.787), was observed among a higher proportion of the controls (20.5%) than observed among the cases (18.4%). This study documented no significant differences between children with light (less than 50 ova per 10 ml urine) and heavy (more than 50 ova per 10 ml urine) infection. This study documented no significant variation in the biochemical markers of renal function between the cases and controls. S. haematobium Infection intensity did not significantly alter the renal physiology of the school children studied.