Withanone from Withania somnifera Attenuates SARS-CoV-2 RBD and Host ACE2 Interactions to Rescue Spike Protein Induced Pathologies in Humanized Zebrafish Model.

Acharya BalkrishnaSubarna PokhrelHoshiyar SinghMonali JoshiVallabh Prakash MulaySwati HaldarAnurag Varshney

Published in: Drug design, development and therapy (2021)

In conclusion, this study provided experimental validation for computational insight into the potential of withanone as a potent inhibitor of SARS-CoV-2 coronavirus entry into the host cells.

Keyphrases

sars cov
respiratory syndrome coronavirus
induced apoptosis
diabetic rats
cell cycle arrest
angiotensin ii
oxidative stress
drug induced
angiotensin converting enzyme
risk assessment
signaling pathway
binding protein
human health
small molecule
protein protein
stress induced