Dichotomous role of Shp2 for naïve and primed pluripotency maintenance in embryonic stem cells.
Seong-Min KimEun-Ji KwonYun-Jeong KimYoung-Hyun GoJi-Young OhSeokwoo ParkJeong Tae DoKeun-Tae KimHyuk-Jin ChaPublished in: Stem cell research & therapy (2022)
Taken together, our findings highlight the differential roles of Shp2 in naïve and primed pluripotency and propose the usage of iShp2 instead of iMek1 for the efficient maintenance and establishment of naïve pluripotency.
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