Hyperglycemia activates the renin-angiotensin system and induces epithelial-mesenchymal transition in streptozotocin-induced diabetic kidneys.

Chung-Ming ChenShu-Hui JuanHsiu-Chu Chou

Published in: Journal of the renin-angiotensin-aldosterone system : JRAAS (2019)

We demonstrate that hyperglycemia activated the renin-angiotensin system, induced epithelial-mesenchymal transition, and contributed to kidney fibrosis in an experimental diabetes mellitus model.

Keyphrases

diabetic rats
epithelial mesenchymal transition
oxidative stress
high glucose
transforming growth factor
signaling pathway
type diabetes
drug induced
endothelial cells
adipose tissue
insulin resistance
glycemic control