Validation of Myc-Associated Protein X (MAX) regulation in growth hormone secreting and nonfunctional pituitary adenoma.

Douglass W TuckerDhiraj J PangalRobin DuAngad S GogiaAli TafreshiJacob RuzevickKyle T HurthTim TricheAlexander S G MickoJohn D CarptenMark S ShiroishiJohn D CarmichaelSuhn K RhieGabriel Zada

Published in: PloS one (2023)

GHPA have significantly different DNA methylation and downstream protein expression levels of MAX compared to NFPA. These differences may influence mechanisms involved with cellular proliferation, tumor invasion and hormonal secretion.

Keyphrases

growth hormone
dna methylation
genome wide
signaling pathway
gene expression
cell migration
transcription factor
polycystic ovary syndrome
neuroendocrine tumors
copy number