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Trapping a somatic endogenous retrovirus into a germline piRNA cluster immunizes the germline against further invasion.

Céline DucMarianne YothSilke JensenNolwenn MouniéeCasey M BergmanChantal VauryEmilie Brasset
Published in: Genome biology (2019)
Transposons can hijack the host developmental process to propagate whenever their silencing is lost. Here, we show that the germline can protect itself by trapping invading somatic-specific TEs into germline piRNA clusters. This is the first demonstration of "auto-immunization" of a germline endangered by mobilization of a surrounding somatic TE.
Keyphrases
  • dna repair
  • copy number
  • dna damage