Autophagy gene Atg7 regulates the development of radiation-induced skin injury and fibrosis of skin.

Xinyi ChenWan QinLu WangYu JinJingyao TuXianglin Yuan

Published in: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2023)

In conclusion, Atg7 and autophagy-related mechanisms confer radioprotection, and reactivation of the autophagy process can be a novel therapeutic strategy to reduce and prevent the occurrence of radiodermatitis, particularly skin fibrosis, in patients with cancer.

Keyphrases

radiation induced
cell death
endoplasmic reticulum stress
soft tissue
signaling pathway
oxidative stress
wound healing
radiation therapy
risk assessment
copy number