Association between APOA5 polymorphisms and susceptibility to metabolic syndrome: a systematic review and meta-analysis.
Sima MozafariMarziyeh AshooriSeyed Mahdi Emami MeybodiRoya SolhiSeyed Reza MirjaliliAli Dehghani FiroozabadiSepideh SoltaniPublished in: BMC genomics (2024)
The present findings suggest that polymorphisms located in the promoter and coding regions of the APOA5 gene are associated with an increased prevalence of MetS in the adult population. Identifying individuals with these genetic variations could lead to early disease detection and the implementation of preventive strategies to reduce the risk of MetS and its related health issues. However, because the sample size was small and there was evidence of significant heterogeneity for some APOA5 gene polymorphisms, these results need to be confirmed by more large-scale and well-designed studies.
Keyphrases
- metabolic syndrome
- healthcare
- genome wide
- copy number
- dna methylation
- public health
- primary care
- risk factors
- mental health
- insulin resistance
- transcription factor
- single cell
- uric acid
- quality improvement
- health information
- label free
- cardiovascular risk factors
- real time pcr
- genome wide identification
- skeletal muscle