Phenotypic and functional alterations of peritoneal macrophages in lupus-prone mice.

Gabriela TejonNicolás ValdiviesoFelipe Flores-SantibañezVerónica Barra-ValdebenitoVíctor MartínezMario RosemblattDaniela SaumaMaría Rosa Bono

Published in: Molecular biology reports (2022)

The increase of macrophages with an altered phenotype and function together with the accumulation of B1a cells in the peritoneal cavity of diseased-BWF1 mice may promote the progression of the disease. Advancing awareness of the role and phenotype of peritoneal macrophages in SLE may contribute to a better understanding of these types of diseases and the development of novel therapies.

Keyphrases

systemic lupus erythematosus
high fat diet induced
induced apoptosis
disease activity
cell cycle arrest
wild type
type diabetes
oxidative stress
signaling pathway
skeletal muscle
metabolic syndrome
cell death
cell proliferation
pi k akt